杨千帆 杨千帆

最小化 最大化

杨千帆

出生年月：1981.10 籍贯：四川乐山

联系方式：yangqf@iccas.ac.cn

 

教育与工作背景

2010.7-2015.10 中国科学院化学研究所 副研究员

2005.9-2010.7 中国科学院化学研究所 博士

2004.7-2005.9 中国科学院化学研究所 实验室助理

2000.9-2004.7 北京化工大学 学士

 

发表文章

  1. Gai, W., Yang, Q.*, Xiang, J., Yu, L., Guan, A., Li, Q., Sun, H., Shang, Q., Jiang, W., Zhang, H., Liu, Y., Wang, L., Tang, Y.* (2013) Novel Dual-Functional Regulation of a Chair-Like Antiparallel G-quadruplex on Inducing Assembly/Disassembly of Cyanine Dye. Phys. Chem. Chem. Phys., 15, 5758-5761..
  2. Gai, W., Yang, Q.*, Xiang, J., Jiang, W., Li, Q., Sun, H., Guan, A., Shang, Q., Zhang, H. and Tang, Y.*, (2013) A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)]4 and cyanine dye 2, 2¢-diethyl-9-methyl-selenacarbocyanine bromide. Nucleic Acids Res., 41 (4), 2709-2722.
  3. Gai, W., Yang, Q.*, Xiang, J., Jiang, W., Li, Q., Sun, H., Yu, L., Shang, Q., Guan, A., Zhang, H. and Tang, Y.*, (2013) A novel signal-amplified strategy based on assembly reactivation for highly specific and sensitive detection of chair-like antiparallel G-quadruplex. Analyst, 138 (3), 798-804. (Hot Article)
  4. Gai, W., Yang, Q.*, Xiang, J., Sun, H., Shang, Q., Li, Q., Jiang, W., Guan, A., Zhang, H., Tang, Y.* and Xu, G., (2013) Roles of flanking sequences in the binding between unimolecular parallel-stranded G-quadruplexes and ligands. Chin. Sci. bull., 58, 731-740. (Cover Article)
  5. Ng, N., Leverett, P., Hibbs, D., Yang, Q., Bulanadi, J., Wu, M., Aldrich-Wright, J.*, (2013) The antimicrobial properties of some copper(II) and platinum(II) 1,10-phenanthroline complexes. Dalton Trans. 42, 3196-3209.
  6. Yang, Q., Xiang, J., Yang, S., Li, Q., Zhou, Q., Guan, A., Lin, L., Zhang, X., Zhang, H., Tang, Y. and Xu, G. (2010) Verification of Intramolecular Hybrid/Parallel G-quadruplex Structure under Physiological Condition by Using Novel Cyanine Dye H-aggregates: both in Solution and on Au Film. Anal. Chem., 82 (22), 9135–9137.
  7. Yang, Q., Xiang, J., Yang, S., Li, Q., Zhou, Q., Guan, A., Zhang, X., Zhang, H., Tang, Y. and Xu, G. (2010) Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanism. Nucleic Acids Res., 38, 1022-1033.
  8. Yang, Q.; Xiang, J.; Yang, S.; Li, Q.; Zhou, Q.; Guan, A.; Zhang, X.; Zhang, H.; Tang, Y.; Xu, G.; (2010) Recognizing hybrid/mixed G-quadruplex in human telomeres by using a cyanine dye supramolecule with confocal laser scanning microscopy. Chin. J. Chem., 28 (7), 1126-1132.
  9. Yang, Q., Xiang, J., Yang, S., Zhou, Q., Li, Q., Tang, Y. and Xu, G. (2009) Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: I. Recognizing mixed G-quadruplex in human telomeres. Chem. Commun., 1103-1105.
  10. Yang, Q., Xiang, J., Li, Q., Yan, W., Zhou, Q., Tang, Y. and Xu, G. (2008) Chiral Transformation of Cyanine Dye Aggregates Induced by Small Peptides. J. Phys. Chem. B, 112, 8783-8787.
  11. Zhou, Q., Li, L., Xiang, J., Tang, Y., Zhang, H., Yang, S., Li, Q., Yang, Q. and Xu, G. (2008) Screening Potential Antitumor Agents from Natural Plant Extracts by G-Quadruplex Recognition and NMR Methods. Angew. Chem.-Int. Edit., 47, 5590-5592.
  12. Guan, A., Zhang, E., Xiang, J., Yang, Q., Li, Q., Sun, H., Wang, D., Zheng, Q., Xu, G. and Tang, Y. (2012) Regulating the Conformation of Methylazacalix[6]pyridine by Oligonucleotide BCL-2 2345 and Its Recognition of Hydroxymethylpiperazinofullerene. J. Phys. Chem. Lett., 3, 131-135.
  13. Guan, A., Zhang, E., Xiang, J., Li, Q., Yang, Q., Li, L., Tang, Y. and Wang, M. (2011) Effects of Loops and Nucleotides in G-Quadruplexes on Their Interaction with an Azacalixarene, Methylazacalix[6]pyridine. J. Phys. Chem. B, 115, 12584-12590.
  14. Zhang, X., Xiang, J., Tian, M., Yang, Q., Sun, H., Yang S,. and Tang, Y. (2009) Formation of an Intramolecular G-Quadruplex of Human Telomere Induced by Poly(l-lysine) under Salt-Deficient Conditions. J. Phys. Chem. B, 113 (21), 7662–7667.
  15. Li, Q., Xiang, J., Li, X., Chen, L., Xu, X., Tang, Y., Zhou, Q., Li, L., Zhang, H., Sun, H., Guan, A., Yang, Q., Yang, S. and Xu, G. (2009) Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves. Biochimie, 91, 811-819.
  16. Zhang X., Zhang H., Xiang J., Li Q., Yang Q., Shang Q., Zhang Y., Tang Y.* (2010) The binding modes of carbazole derivatives with telomere G-quadruplex. J. Mol. Struct., 982, 133-138.
  17. Sun, H.; Xiang, J.; Gai, W.; Shang, Q.; Li, Q.; Guan, A.; Yang, Q.; Liu, Y.; Tang, Y.; Xu, G., (2012) Visual detection of potassium by a cyanine dye supramolecular aggregate responsive to G-quadruplex motif transition. Analyst, 137 (24), 5713-5.
  18. Sun, H., Xiang, J., Zhou, Q., Yang, Q., Xu, G., Tang, Y. (2010) Temperature-sensitive supramolecules self-assembled by G-quadruplex DNA. Int. J. Biol. Macromol., 64(1), 123-125.
  19. Sun, H., Xiang, J., Yang, Q., Shang, Q., Zhou, Q., Zhang, Y., Xu, G., Tang, Y. (2011) Controllable assembly and cycling conversion of various supramolecular aggregates of a cyanine dye. Appl. Phys. Lett., 98(3), 031103 - 031103-3.
  20. Yang, S., Xiang, J., Yang, Q., Li, Q., Zhou, Q., Zhang, X., Tang, Y., Xu, G.. (2011) Formation of Human Telomeric G-quadruplex Structures Induced by the Quaternary Benzophenanthridine Alkaloids: Sanguinarine, Nitidine, and Chelerythrine. Chin. J. Chem., 28, 771-780.
  21. Yang, S., Xiang, J., Yang, Q., Zhou, Q., Zhang, X., Li, Q., Tang, Y., Xu, G. (2011) An important functional group: Benzo[1,3]dioxole, of Alkaloids to induce the formation of human telomeric DNA G-quadruplex. Chin. Sci. Bull., 56, 613-617.
  22. Yang, S., Xiang, J., Yang, Q., Zhou, Q., Zhang, X., Li, Q., Tang, Y., Xu, G. (2010) Distinct G-quadruplex structures of human telomeric DNA formed by the induction of Sanguinarine and Nitidine under salt-deficient condition. Fitoterapia, 81, 1026-1032.
  23. Zhang, Y., Yang, Q., Du, H., Tang, Y., Xu, G. and Yan, W. (2008) Spectroscopic investigation on the interaction of a cyarline dye with serum albumins. Chin. J. Chem., 26, 397-401.
  24. Zhou, Q.; Xiang, J.; Tang, Y.; Liao, J.; Yu, C.; Du, H.; Yang, Q. and Xu, G., (2008) Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso- propylidenedioxy-1-oxacyclopentane-5,5'-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin. Pest. Biochem. Physiol., 29(1), 43-47.
  25. 杨舒，刘岩，杨千帆，向俊锋，唐亚林，徐广智（2011）博落回抗肿瘤作用及诱导人体端粒DNA形成G-四链体分子机制研究，中草药，42 (4), 738-742.

 

出版著作

  1. Shang Q., Xiang J., Yang Q. and Tang Y., Interaction Between Aggregates of Cyanine Dyes and Biomolecules, in J-Aggregates Volume 2, T. Kobayashi, Editor. 2012, World Scientific Publishing Company. （专著）

 

申请专利

  • 国际PCT专利（国际阶段）
    1. 诊断白血病的方法、试剂盒和系统，PCT/CN2013/071728
  • 已授权国内发明专利
    1. 菁染料在检测G-四链体结构DNA中的新用途，ZL 200810112394
  • 已申请国内发明专利
    1. 超分子有序体在检测G-四链体结构DNA中的应用，200810112393
    2. 用于诊断白血病的试剂盒，201210041112.2
    3. 用于诊断白血病的系统，201210041131.5
    4. 菁染料的新用途，201210164349.X
    5. 菁染料的新用途，201210164341.9
    6. 用于检测乳腺癌的系统，201210164367.8
    7. 用于诊断白血病的试剂盒和系统，201210164310.8
    8. 钾离子浓度检测方法，201210206227.2
    9. 钾离子浓度检测试剂盒和系统，201210207722.5
    10. 钾离子浓度检测方法，201210205843.6
    11. 钾离子浓度检测试剂盒，201210205861.4
    12. 检测钠/钾离子比的方法和试剂盒以及系统，201210553125.8
    13. 钠/钾离子比的方法、系统和试剂盒，201210553784.1
    14. 尿微量白蛋白检测方法、系统和试剂盒，201310027507.1
    15. 尿微量白蛋白检测方法和试剂盒，201310027719.x